SENS · Biotechnology and bioprocesses
Solutions for molecular characterization, online monitoring and biomass analysis, substrates, products and metabolic routes by elemental composition and isotope signatures.
Analytical areas
The areas below bring together complementary techniques for laboratory characterization, process monitoring and investigation of composition or metabolism.
Laboratory characterization
Characterize culture media, proteins, formulations, biomolecules and products by absorbance, fluorescence and Raman, in laboratory or at-line measurements.
In-line process monitoring
Follow molecular attributes by Raman and the gas phase by mass spectrometry. The objective is to observe trends, transitions and deviations with minimal interference in the operation.
Composition and tracing
Characterize biomass, media, substrates and products; investigate the origin and incorporation of elements; and preserve the molecular context in studies with isotopologues.
Related portfolio
The final selection depends on the matrix, the analytical range, the need for an online or laboratory response and the experimental design.
Molecular signatures and chemometric models for online monitoring.
Online mass spectrometry of off-gas from fermenters and bioreactors.
CHNS/O, C/N ratio and total nitrogen/protein.
isotope ratios for bioprocess origin, incorporation and balances.
Exact mass and isotopic information preserving the molecular context.
Areas of application
The solutions answer questions in research, development, optimization and analytical characterization.
Monitoring of metabolites, gases, breathing and volatile by-products.
Raman monitoring, perfusion, upstream and biomass characterization.
Composition of raw materials, yield, carbon origin and products.
PAT strategies, stability, culture media and upstream processes.
CHNS/O, C/N, protein and comparison between substrates, currents and products.
Incorporation of C, N, H, O and S and investigation of metabolic pathways.
Analytical planning
We can evaluate matrix, critical variable, concentration range, response time, sampling, isotopic tracers and integration between techniques.