01
Cell-culture media
Batch comparison and composition variability.
HORIBA Solutions / HORIBA Veloci BioPharma Analyzer
A-TEM for biopharmaceuticals
HORIBA Veloci BioPharma Analyzer
Fast molecular Fingerprint for bioprocess monitoring, media variability, protein comparability and stability.
A-TEEMfingerprint
fastCase decision
no reagentsoptical measurement
Summary
Veloci applies A-TEM and multivariate analysis to biopharmaceutical samples, providing rapid and complementary information for process development and control.
Solution overview
Converting spectra into process signals
The combination of absorbance and EEM captures global changes in the sample. Chemometric models can relate fingerprints to concentration, stability or process status when properly calibrated.
Applications
Primary applications
02
Cell culture
Growth monitoring and process changes.
03
Proteins and mAbs
Fingerprint, comparability and stability studies.
Key features
Resources and settings
01
Quick measurement
Reduces response time in screening steps.
02
Low consumption
Optical flow with little sample and no analytical reagents.
03
Multivariate models
They convert spectral profiles into classifications or estimates after validation.
Reference data
Technical view
This summary supports preliminary evaluation; the final configuration must account for the sample matrix, method, analytical range and throughput.
TechnologyA-TEEM
AreaBiopharmaceuticals and bioprocesses
OutputsFingerprint, classification, trend and quantitative models
Analytical paperQuick screening and complementary tool
Frequently Asked Questions
Technical information
Does Veloci replace chromatographic methods?
Not universally. It can reduce screenings and provide rapid response, but compendial and confirmatory methods remain necessary when applicable.
Do we need to calibrate models?
Yes. Quantitative or classifier applications require representative set, validation and model maintenance.
Can it compare cell-culture media lots?
Yes. Fingerprints A-TEM may show variability between batches and support research impact on bioprocess.
Related pages
Related solutions
Application assessment
Inform the matrix, analytes or molecules of interest, expected range and volume of samples. SENS specifies the applicable configuration.